The present study was carried out to determine the antipyretic activity of the
methanolic extract of Blumea lacera leaves (BLE) on albino rats. Acute toxicity study of BLE was
performed by limit test as per OECD guideline. Antipyretic activity was studied by inducing pyrexia
with Brewer's yeast. Acute oral LD50 of BLE in female rats was more than 2000 mg/kg. Three
ascending doses of 100 (1/20 LD50), 200 (1/10 LD50) and 400 mg/kg (1/5 LD50) were selected for
studying the antipyretic activity of BLE in rats. BLE at dose rates of 200 and 400 mg/kg reduced
brewer's yeast induced pyrexia in rats suggesting antipyretic effect of BLE.
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Author Name: Lokesh K. Verma1 , Aruna K. Singh*, Vaibhav R. Pachade1 , K.M. Koley1 and V.P.Vadlamudi1
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Keywords: Blumea lacera, Albino rats, Brewer's yeast, Antipyretic.
ISSN: 2277-470X
EISSN: 2319-247X
EOI/DOI:
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