Background: Treatment guidelines for allergic rhinitis (AR) recommend use of intranasal corticosteroids (INSs) as mono or adjunctive therapy. However, the adverse event (AE) profiles of oral glucocorticoids, which result largely from systemic absorption of these agents, have raised concerns about their safety. These concerns persist for INSs despite marked clinical differences between them and systemic corticosteroids in absorption and among the INSs in bioavailability, mechanism of action, and lipophilicity, which may contribute to differences in AEs. Objective: To study the safety profile of different topical intranasal steroids used for treatment of allergic rhinitis and comparison oftheir efficacy and adverse events. Study design: Prospective study Setting: This study was conducted in ENT department at Era’s Lucknow Medical College and Hospital, Lucknow Patients: 135 patients of allergic rhinitis. Results: The statistical tests applied were repeated measures ANOVA and the chi squared tests. Conclusions: From this study it can be concluded that the three INS showed beneficial effect on allergic rhinitis. However, with respect to side effects and diminution of symptom scores, nasal endoscopy score and AEC count no significant difference among the groups was found. All three groups were almost similar in their treatment efficacy and side effect profile

Author Name: Syed Mohd Faiz, Rajeev Krishna Gupta, Saurabh Srivastava

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Keywords: Intranasal steroids (INS), allergic rhinitis (AR), adverse events (AE), Fluticasone propionate (FP), Mometasonefuroate (MF), Fluticasone Furoate (FF).

ISSN: 0974-5262

EISSN:

EOI/DOI: 10.21176/ojolhns.2018.12.1.8

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