Background: celiac disease (CD) is an autoimmune disorder that is common in the general population.
Early serological diagnosis of CD access to treatment and improves the patient's quality of life.
Objectives: to explore the rate of CD among clinically suspected children in using serological tests
and to assess the validity of these markers for the diagnosis of CD.
Materials and methods: This case control study was conducted in Diyala province-Iraq during the
period from September 2011 to April 2012 in Al-Batool Teaching Hospital for Maternity and Children.
156 children who were clinically suspected as having CD and 124 healthy children as control
group were enrolled. The patient's age range was 1 month to 6 years and above. Information regarding
age, sex, residence, family history, and clinical signs were collected in a special questionnaire.
Commercially available serological kits for anti-gliadin IgA (AGA-IgA) and anti- tissue transglutaminase
IgA (anti-tTG-IgA) antibodies (Aeskulisa, Germany) were used by ELISA technique. Data
were statistically analyzed and P value less than 0.05 was considered significant.
Results: Based on the seropositivity of both anti-AGA IgA and anti-tTG IgA, 15 (9.6%) were considered
CD patients. whereas, patients who had either anti-AGA IgA (16.7%) or anti-tTG IgA (14.7%)
positive were considered as symptomatic non-CD patients. The results showed that the anti-AGA IgA
seropositivity was highly significant (P< 0.001) in CD patients compared to symptomatic non-CD patients
and control groups. Likewise, the anti-tTG IgA positivity was highly significant (P< 0.001) in CD
patients compared to symptomatic non-CD patients and control groups. Both tests had similar sensitivity,
but the anti-tTG IgA has higher specificity, accuracy, and positive predictive value.
Conclusion: Serum Anti-tTG IgA is a good marker for the diagnosis of CD among clinically suspected
patients; however, for more accuracy both anti-tTG IgA and anti-AGA IgA can be used.
Real Time Impact Factor:
Pending
Author Name: Assis. Prof. Dr. Abdulrazak SH. Hasan *, Prof. Dr. Nadhim Gh. Noaman **, Assis. Prof. Dr. Mehdi SH. Al-Zuheiry ***, Shahad KH. Al-Qaisi ****
URL: View PDF
Keywords: CELIAC DISEASE. ANTI-GLUTIN. ANTI-TRANSGLUTINASE
ISSN: 2001-9211
EISSN: 2001-9211
EOI/DOI:
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