The coordinating character of 5-Fluorouracil (5-FU) with N and O sites towards some metal ion Ni(II) have been synthesized and characterized by elemental, spectral (UV and IR spectroscopy) data as well as by magnetic moment values and conductivity measurements. The amperometric & elemental analysis suggests that the stoichiometry of the Metal: 5-FU 1:1. The low molar conductance values reveal the non-electrolytic nature of the complex. Magnetic moment values in concert with the electronic spectra indicate that 5-FU coordinates with the metal ion in a bidentate manner through the C = O and N atoms. The antimicrobial activity of the synthesized complex also screened against bacteria such as Bacillus subtilis, Staphylococcus saphyphiticus, Staphylococcus aureus & Escherichia coli. Ni (II): 5- FU ligand complex shows an increased activity in comparison to the control.

Author Name: AGRAWAL SHUCHITA, JOSHI AJIT, JAIN SANCHITA

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Keywords: Metal ligand complex, 5-Fluorouracil, Spectral studies, and Antimicrobial activity.

ISSN: 2455-6203

EISSN: 2455-6203

EOI/DOI:

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