Background: The emergence of highly active antiretroviral therapy (HAART) has led to dramatic improvements in prolonging the life expectancy of HIV-infected patients. However, long-term use may cause kidney derangements that may be life-threatening. Objective: This present study seeks to assess the levels of microalbuminuria and myoglobin in HIV positive subjects. Materials and Methods: One hundred and fifty subjects [50 HIV negative, 50 positive HAART naïve and 50 HAART treated subjects] were enrolled in the study. Plasma creatinine, urea, uric acid, myoglobin and urine microalbumin were assayed using standard methods. Results: Microalbuminuria was significantly higher (p<0.001) in HIV positive than HIV negative subjects, while the differences in the levels of urea, creatinine, uric acid and myoglobin were insignificant. The levels of urea (p<0.001), creatinine (p<0.018) and uric acid (p<0.001) were significantly higher in HIV positive HAART naïve than HIV positive on HAART. Even though the levels of microalbuminuria were higher while myoglobin was lower in HIV positive HAART naïve than HIV positive on HAART, the difference was not statistically significant. Conclusion: The levels of measured markers of renal function were higher in HIV positive subjects whether or not on HAART treatment. However, HAART treatment did not adversely affect renal function in this study.

Author Name: Adeleke, T.D. & Emokpae M.A.

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Keywords: HIV, HAART, Microalbuminuria, myoglobin

ISSN: 1116-1043

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