Introduction. The major and most common mechanisms for almost all antimicrobial substances are the induction of oxidative stress responses within the pathogen cells by the accumulation of free radicals, which mediate a whole range of classical antimicrobial mechanisms of action observed by researchers. Thus, this present study was conducted to reveal some biochemical changes regarding the antioxidant status of pathogenic microorganisms under the influence of novel chemical compounds selected. Material and methods. The copper (II) coordination compounds were included as in vitro study material, namely, Co (II), Zn (II), and aromatic propenones, synthesized at the Department of Inorganic Chemistry, the State University of Moldova. The antimicrobial properties were tested on five reference strains. The ABTS test was applied to determine the antioxidant activity, thus determining the total antioxidant capacity using the!BTS? + cation radical. Results. The most vulnerable to high-intensity oxidative stress are the reference strains of Staphylococcus aureus!TCC 2592 and Bacillus cereus ???? 8035, the most resistant being the reference culture Salmonella enterica (S. Abony ???? 03/03y). Conclusions. The study results showed that the selected compounds might substantially reduce the total antioxidant capacity in the studied reference cultures.

Author Name: Carolina LOZAN-TIRSU

URL: View PDF

Keywords: antimicrobial activity, antioxidant activity, chemical compounds, copper, reference strains

ISSN: 2587-3458

EISSN: 2587-3466

EOI/DOI: 10.38045/ohrm.2020.1.16

Add Citation Views: 1

---