The orthotopic ileocystoplasty is the most preferred urine derivation
method for patients after removal of the bladder. The best quality
of life, self-esteem, cosmetic appearance of one’s own body, and
the possibility of physiological urination characterize the artificial
bladder as the “gold standard” of urine derivation. There are a
greater number of postoperative complications associated with
the functionality of the neobladder, considering the complexity of
orthotopic derivation of urine. The autocaturation is required in
some patients day or night urinary incontinence, and in the
other group, periodic urinary retention. Urinary retention is more
common in women up to 43 % compared with 20 % in men, who
need intermittent catheterization.
The aim of investigation was to evaluate the possibility of
pharmacological correction of contractile activity of mini-pigs
neobladder in vivo, under the influence of new chemical
compounds and the anticholinesterase drug nivalin.
Materials and methods Experimental studies were performed on
21 female mini-pigs, with an average age of 6 to 14 months. The
duration of the experiment was 12 months. Performing of
enterocystometry in experimental animals is possible only under
anesthesia and, accordingly, only part of the urodynamic parameters
can be obtained.
Results. The obtained results of in vivo experimental studies
demonstrated the constrictor activity of the studied new chemical
compounds. Compound I in comparison with the control group
statistically significantly increased basal tone by 62.09 %, the
amplitude of contractions by 37.34 %, and the duration of
contractions by 35.71 %. The new chemical compound II, in
comparison with the control group, showed less pronounced results
of constrictor activity, so the basal tone statistically significantly
increased by 38.86 %, and the amplitude of contractions by 15.0 %.
Conclusion. Thus, under the influence of new chemical compounds
in the conditions of an experimental artificial bladder, constrictor
properties are proved, which require further research and study.
In turn, cholinomimetic nivalin has prospects for use in urology,
in particular in patients with hypoactive forms of artificial and
neurogenic bladder.
Real Time Impact Factor:
Pending
Author Name: R.V. Savchuk, F.I. Kostyev, N.V. Shmatkova
URL: View PDF
Keywords: cystectomy, ileocystoplasty, constrictor properties, new chemical compounds, n i v a l i n , a r t i f i c i a l b l a d d e r , enterocystometry, in vivo
ISSN: 2307-5279
EISSN: 2709-5576
EOI/DOI: 10.26641/2307-5279.25.2.2021.2
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