Medular carcinoma (MC) is a subtype of colon carcinoma, it only represents <1% of CRC. It has clinicopathological features that distinguish it from adenocarcinomas (ADC) and other histological variants, although it usually is misdiagnosed as poorly differentiated ADC (PDA) or undiferentiated ADC (UDA) at first. A 57-year-old female presented an intermittent abdominal pain. Laboratory and imaging analyzes reveal serum elevation of the CA 19-9 tumor marker and multiple liver lesions with radiological features of metastasis, a colonoscopy reveals a mamelon lesion that occupies 80% of the lumen of the right colon. A biopsy is performed with a diagnosis of APD. Chemotherapy treatment is initiated with partial improvement, however, months later the patient is admitted to the hospital with an abdominal pain clinic and no stools for a week; so an emergency hemicolectomy is performed. Pathological anatomy analysis describes tumor cells arranged in a solid pattern, with eosinophilic cytoplasm, prominent nucleolus and monocyte inflammatory infiltration; the immunohistochemical test reveals a strong and diffuse staining for calretinin, as well as positive staining for CK- 7, and negative for CK-20; making the diagnosis of medullary carcinoma of the colon. The conclusion is that an adequate diagnosis from the beginning allows us to indicate the best targeted treatment that guarantees greater survival in this group of patients.

Author Name: Dos Santos Y, Ocanto A.

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Keywords: medullary carcinoma; oncology.

ISSN: 2542-3428

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