A series of novel 5-{[(1H-benzo[d]imidazol-2'-yl)thio]methyl}-3-arylisothiazoles 5(a-f) were synthesized by condensing 3-aryl-5-chloromethyl-isothiazole 3(a,b) and 2-mercapto benzimidazole 4(a-c) using potassium carbonate in DMF. The chemical structure of the newly synthesized compounds was characterized by spectral methods (1H, 13C NMR and LC-MS).The title compounds were screened for their antimicrobial, antioxidant and haemolytic assay. All the synthesized compounds showed less than 5% toxicity towards fresh chicken blood. Compounds 5a and 5f showed significant antibacterial activity against Gram positive and Gram negative bacteria and compounds 5 (a-c) showed better activities against the fungi than 5(d-f). It was also observed that of the synthesized compounds, 5d showed better antioxidant activity than the other synthesized compounds.
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Author Name: Narayana U. Kudva N, C. S. Vicas, V. Srinivasa Murthy, Sumana Y. Kotian, K.Byrappa2, K. M. Lokanatha Rai
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Keywords: Isothiazole derivatives, alkylation, antimicrobial, antioxidant, haemolysis.
ISSN:
EISSN: 2249 –1929
EOI/DOI: nill
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