The acute lymphoblastic leukemia is one of the most
common hematological malignancies in childhood. Among
the various genetic alterations in acute lymphoblastic
leukemia, the fusion gene ETV6/RUNX1, produces a
modification of the normal lymphoid differentiation and
it results from the most common structural chromosomal
abnormality in the pediatric acute lymphoblastic leukemia,
the t(12;21)(p13;q22). Although ETV6/RUNX1 considered
a genetic factor of good response to treatment, its influence
on the prognosis of the acute lymphoblastic leukemia
is controversial because it appears to contribute to the
occurrence of late relapse. We review the role of this gene
fusion in initiation and development of acute lymphoblastic
leukemia as well as genetic and molecular methodological
approaches for identifying such alteration
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Author Name: ROCÍO SILVA-CRUZ, LUCINA BOBADILLA-MORALES, JORGE ROMÁN CORONA-RIVERA, ALFREDO CORONA-RIVERA
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Keywords: Leukemia, lymphoblastic, acute, ETV6/ RUNX1, genetic factor, prognosis.
ISSN: 0798-0582
EISSN: E 2343-6239
EOI/DOI:
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