Acetaminophen (paracetamol) is a synthetic non-opioid derivative of p-aminophenol and basic bioactive molecule in numerous pharmaceutical preparations for the treatment of colds and flu. In combination with opioid analgesics, acetaminophen can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. Design of synthesis of acetaminophen is based on a modern approach of choosing the right synthetic route and using methods necessary for the characterization of the resulting pharmaceutically active compound, thereby providing reliable parameters of the chemical quality of the synthesized molecules. Formation of the preferred form of acetaminophen is a process made up of two stages, where in the first stage an acid catalyzed reaction gives the crude acetaminophen. The reaction takes place according to the mechanism of nucleophilic addition in which the nitrogen atom of the p-aminophenol as nucleophile by attacking a carbonyl group of acetic anhydride forms an intermediate which undergoes the further elimination of the acetate anion. Recrystallization is one of the most common techniques used for purifying drug solids. One of the goals of this study was to achieve the results through the crystallization process in optimum conditions, in order to improve the yield and adequate purity of synthesized acetaminophen. In pharmaceuticals cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of poorly water-soluble drugs through noncovalent inclusion complexation and to increase their bioavailability and stability. Complexation with beta cyclodextrin was attempted to improve solubility of acetaminophen.

Author Name: Majda Srabovic, Melita Huremovic, Benjamin Catovic, Samra Kulic, Aida Taletovic

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Keywords: drugs, acetaminophen, synthesis, cyclodextrins.

ISSN:

EISSN: 2249 –1929

EOI/DOI: nil

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